Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging

Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained their ability to resist...

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Published in:Stem cell research & therapy 2024-03, Vol.15 (1), p.58-58, Article 58
Main Authors: Shin, Eun-Young, Jeong, Suji, Lee, Jeoung Eun, Jeong, Dong Seok, Han, Dong Keun, Hong, Seok-Ho, Lee, Dong Ryul
Format: Article
Language:English
Subjects:
17β-Estradiol
Aging
Apoptosis
Bone marrow
Cell growth
Cell therapy
Comparative analysis
Cytokines
Embryo cells
Embryogenesis
Embryonic stem cells
Estradiol
Ethylenediaminetetraacetic acid
Experiments
Fecundity
Females
Fertility
Fertility preservation of natural aging female
Fibrosis
Follicles
Human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs)
Laboratory animals
Menopause
Myeloid-derived suppressor cells (MDSCs)
Ovarian function
Ovaries
Progenitor cells
Reproductive senescence
Reproductive status
Senescence
Stem cells
Suppressor cells
Transplantation
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container_title Stem cell research & therapy
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creator Shin, Eun-Young
Jeong, Suji
Lee, Jeoung Eun
Jeong, Dong Seok
Han, Dong Keun
Hong, Seok-Ho
Lee, Dong Ryul
description Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained their ability to resist ovarian aging, which leads to delayed reproductive senescence. In a middle-aged female model undergoing natural aging, we analyzed whether hESC-MPCs benefit the long-term maintenance of reproductive fecundity and ovarian reservoirs and how their transplantation regulates ovarian function. The number of primordial follicles and mice with regular estrous cycles were increased in perimenopausal mice who underwent multiple introductions of hESC-MPCs compared to age-matched controls. The estradiol levels in the hESC-MPCs group were restored to those in the young and adult groups. Embryonic development and live birth rates were higher in the hESC-MPC group than in the control group, suggesting that hESC-MPCs delayed ovarian senescence. In addition to their direct effects on the ovary, multiple-treatments with hESC-MPCs reduced ovarian fibrosis by downregulating inflammation and fibrosis-related genes via the suppression of myeloid-derived suppressor cells (MDSCs) produced in the bone marrow. Multiple introductions of hESC-MPCs could be a useful approach to prevent female reproductive senescence and that these cells are promising sources for cell therapy to postpone the ovarian aging and retain fecundity in perimenopausal women.
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To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs). We investigated whether the cells retained their ability to resist ovarian aging, which leads to delayed reproductive senescence. In a middle-aged female model undergoing natural aging, we analyzed whether hESC-MPCs benefit the long-term maintenance of reproductive fecundity and ovarian reservoirs and how their transplantation regulates ovarian function. The number of primordial follicles and mice with regular estrous cycles were increased in perimenopausal mice who underwent multiple introductions of hESC-MPCs compared to age-matched controls. The estradiol levels in the hESC-MPCs group were restored to those in the young and adult groups. Embryonic development and live birth rates were higher in the hESC-MPC group than in the control group, suggesting that hESC-MPCs delayed ovarian senescence. 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subjects 17β-Estradiol
Aging
Apoptosis
Bone marrow
Cell growth
Cell therapy
Comparative analysis
Cytokines
Embryo cells
Embryogenesis
Embryonic stem cells
Estradiol
Ethylenediaminetetraacetic acid
Experiments
Fecundity
Females
Fertility
Fertility preservation of natural aging female
Fibrosis
Follicles
Human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs)
Laboratory animals
Menopause
Myeloid-derived suppressor cells (MDSCs)
Ovarian function
Ovaries
Progenitor cells
Reproductive senescence
Reproductive status
Senescence
Stem cells
Suppressor cells
Transplantation
title Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging
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