Antibiotic envelope is associated with reduction in cardiac implantable electronic devices infections especially for high‐power device—Systematic review and meta‐analysis

Background Infections after cardiac implantable electronic device (CIED) placement are associated with significant morbidity and mortality. The incidence of CIED is increasing overtime despite the optimal use of antimicrobial agents. This systematic review and meta‐analysis will address the latest e...

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Bibliographic Details
Published in:Journal of arrhythmia 2020-02, Vol.36 (1), p.166-173
Main Authors: Pranata, Raymond, Tondas, Alexander Edo, Vania, Rachel, Yuniadi, Yoga
Format: Article
Language:English
Subjects:
Antibacterial agents
antibiotic envelope
Antibiotics
Bias
cardiac implantable electronic device
Clinical trials
Health aspects
Implants, Artificial
Infection
Infections
Medicare
Meta-analysis
Mortality
Original
Pacemakers
Patients
Prosthesis
Sensitivity analysis
Studies
Systematic review
TYRX
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Summary:Background Infections after cardiac implantable electronic device (CIED) placement are associated with significant morbidity and mortality. The incidence of CIED is increasing overtime despite the optimal use of antimicrobial agents. This systematic review and meta‐analysis will address the latest evidence on the use of AE to mitigate the risk of CIED infection, and which subset of patients will they benefit the most. Methods We performed a comprehensive search on topics that assesses antibiotic envelope and implantable cardiac electronic device up until August 2019. Results There were a total of 32,329 subjects from six studies. Antibiotic envelope was associated with a lower risk of major infection with OR 0.42 [0.19, 0.97], P = .04; I2: 58% and HR 0.52 [0.32, 0.85], P = .009; I2: 80%. Upon sensitivity analysis by removing a study, the OR became 0.40 [0.27, 0.59], P 
ISSN:1880-4276
1883-2148
DOI:10.1002/joa3.12270