Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatme...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (22), p.5398
Main Authors: Collier, Nicholas J, Rhodes, Lesley E
Format: Article
Language:English
Subjects:
5-aminolevulinic acid (ALA)
Apoptosis
Basal cell carcinoma
basal cell carcinoma(s) (BCC)
Biomedical Research
Cancer therapies
Carcinoma, Basal Cell - drug therapy
Clinical trials
Drug Development
FDA approval
Humans
methyl aminolevulinate (MAL)
Nanoparticles - chemistry
Pathogenesis
Photochemotherapy
Photodynamic therapy
photodynamic therapy (PDT)
photosensitizer
protoporphyrin IX (PpIX)
Review
Skin cancer
Skin Neoplasms - drug therapy
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description Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatment. It outlines the context of PDT and how PDT treatments for BCC have been developed hitherto. The sections examine the development of systemic and subsequently topical photosensitizers, light delivery regimens, and the use of PDT in different patient populations and subtypes of BCC. The outcomes of topical PDT are discussed in comparison with alternative treatments, and topical PDT applications in combination and adjuvant therapy are considered. The intention is to summarize the clinical relevance and expose areas of research need in the BCC context, ultimately to facilitate improvements in PDT treatment.
doi_str_mv 10.3390/molecules25225398
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subjects 5-aminolevulinic acid (ALA)
Apoptosis
Basal cell carcinoma
basal cell carcinoma(s) (BCC)
Biomedical Research
Cancer therapies
Carcinoma, Basal Cell - drug therapy
Clinical trials
Drug Development
FDA approval
Humans
methyl aminolevulinate (MAL)
Nanoparticles - chemistry
Pathogenesis
Photochemotherapy
Photodynamic therapy
photodynamic therapy (PDT)
photosensitizer
protoporphyrin IX (PpIX)
Review
Skin cancer
Skin Neoplasms - drug therapy
title Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities
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