Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China

Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating prevalence of the H4 subtype heightens the concern for its zoonotic potential, signaling an urge...

Full description

Saved in:
Bibliographic Details
Published in:Virology journal 2024-04, Vol.21 (1), p.85-85, Article 85
Main Authors: He, Jinyue, Deng, Jing, Wen, Xianxian, Yan, Mengyuan, Liu, Yang, Zhou, Yunqiu, Du, XuBin, Yang, Han, Peng, Xiaobin
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Avian flu
Avian influenza
Avian influenza viruses
Distribution
Genes
Genetic aspects
Genomes
Genomics
Identification and classification
Influenza
Live poultry markets
Novel multiplex reassortant virus
Nucleotide sequence
Poultry
Risk factors
Southwest China
Subtype H4N1
Vigilance
Viruses
Waterfowl
Zoonoses
Zoonotic potential
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating prevalence of the H4 subtype heightens the concern for its zoonotic potential, signaling an urgent need for vigilance. During the period from December 2021 to November 2023, we collected AIV-related environmental samples and assessed them using a comprehensive protocol that included nucleic acid testing, gene sequencing, isolation culture, and resequencing. In this study, a total of 934 environmental samples were assessed, revealing a remarkably high detection rate (43.66%, 289/662) of AIV in the live poultry market. Notably, the H4N1 subtype AIV (cs2301) was isolated from the live poultry market and its complete genome sequence was successfully determined. Subsequent analysis revealed that cs2301, resulting from a reassortment event between wild and domesticated waterfowl, exhibits multiple mutations and demonstrates potential for host transfer. Our research once again demonstrates the significant role of wild and domesticated waterfowl in the reassortment process of avian influenza virus, enriching the research on the H4 subtype of AIV, and emphasizing the importance of proactive monitoring the environment related to avian influenza virus.
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-024-02352-8