Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet

Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and ca...

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Bibliographic Details
Published in:Foods 2024-01, Vol.13 (2), p.273
Main Authors: Li, Xin, Cai, Zifan, Yang, Feiyu, Wang, Yunfan, Pang, Xinyi, Sun, Jing, Li, Xiangfei, Lu, Yingjian
Format: Article
Language:English
Subjects:
Analysis
Anti-inflammatory diet
Blood sugar
Broccoli
Cholesterol
Chronic illnesses
Cytokines
Diabetes
Diabetes mellitus (non-insulin dependent)
Diet
Diet therapy
Disease
Flora
Glucose
Inflammation
inflammation factors
Insulin
Insulin resistance
insulin sensitivity
intestinal flora
Intestinal microflora
Intestine
Laboratory animals
Lipid metabolism
Lipids
Lipoproteins
Liver
Low density lipoprotein
Low density lipoproteins
Metabolism
Metabolites
Microbiota (Symbiotic organisms)
Osteoporosis
Oxidative stress
Pancreas
Relative abundance
Rikenellaceae
SCFAs
Tumor necrosis factor-TNF
Type 2 diabetes
type 2 diabetes mellitus
Vegetables
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Summary:Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and carried out a systematic investigation to clarify the function of broccoli in reducing T2DM symptoms and controlling intestinal flora. The findings demonstrated that broccoli could successfully lower fasting blood glucose (FBG), lessen insulin resistance, regulate lipid metabolism, lower the levels of TC, TG, LDL-C, and MDA, stop the expression of IL-1β and IL-6, and decrease the harm that diabetes causes to the pancreas, liver, fat, and other organs and tissues. Furthermore, broccoli altered the intestinal flora's makeup in mice with T2DM. At the genus level, the relative abundance of decreased, and that of and increased; At the family level, the relative abundances of Odoribacteraceae, Rikenellaceae and S24-7 decreased, while the relative abundances of Erysipelotrichaceae and Rikenellaceae increased.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods13020273