An Overview of Methotrexate Indications in Skin Diseases

Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardize...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2024-06, Vol.60 (7), p.1024
Main Authors: Mocanu, Mădălina, Procopciuc, Dorina, Gheucă-Solovăstru, Dragoș-Florin, Popescu, Ioana Adriana, Olinici, Doinița Temelie, Pătrașcu, Adriana Ionela, Vâță, Dan, Gheucă-Solovăstru, Laura
Format: Article
Language:English
Subjects:
Adenosine
Bioavailability
Caffeine
Cytokines
Dermatologic Agents - pharmacology
Dermatologic Agents - therapeutic use
Dihydrofolate reductase
Enzymes
Fibroblasts
Gene expression
Humans
Immunosuppressive Agents - therapeutic use
Lymphocytes
methotrexate
Methotrexate - therapeutic use
Neutrophils
off-label indications
Oral administration
Physiology
Psoriasis
Psoriasis - drug therapy
Rheumatoid arthritis
Skin diseases
Skin Diseases - drug therapy
Toxicity
Vitamin B
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Summary:Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina60071024