Loading…
An Overview of Methotrexate Indications in Skin Diseases
Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardize...
Saved in:
| Published in: | Medicina (Kaunas, Lithuania) Lithuania), 2024-06, Vol.60 (7), p.1024 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 7 |
| container_start_page | 1024 |
| container_title | Medicina (Kaunas, Lithuania) |
| container_volume | 60 |
| creator | Mocanu, Mădălina Procopciuc, Dorina Gheucă-Solovăstru, Dragoș-Florin Popescu, Ioana Adriana Olinici, Doinița Temelie Pătrașcu, Adriana Ionela Vâță, Dan Gheucă-Solovăstru, Laura |
| description | Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies. |
| doi_str_mv | 10.3390/medicina60071024 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_5dddabe671c148b6b4e76f46481b4c3e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_5dddabe671c148b6b4e76f46481b4c3e</doaj_id><sourcerecordid>3084950619</sourcerecordid><originalsourceid>FETCH-LOGICAL-c318t-22a56145911c9a3291b70ccc076f505964831c32898916d23838315baa97d88c3</originalsourceid><addsrcrecordid>eNpdkUtPAyEUhYnRWF97V2YSN26q3OExsDQ-m2i6UNeEYW6V2g4K06r_XmprYwwJ3MB3zr3kEHII9JQxTc-m2HjnWysprYCWfIPsgOSqr4HzzT91j-ymNKaUlaIqt0kvayXngu0Qdd4WwznGucePIoyKe-xeQhfx03ZYDNpsbzsf2lT4tnh4zdulT2gTpn2yNbKThAerc488XV89Xtz274Y3g4vzu75joLp-WVohgQsN4LRlpYa6os45WsmRoELnCRk4ViqtNMimZCovELW1umqUcmyPDJa-TbBj8xb91MYvE6w3PxchPhsbO-8maETTNLZGWYEDrmpZc8xdeG4BNXcMs9fJ0usthvcZps5MfXI4mdgWwywZRpUA0FyzjB7_Q8dhFtv80wXFtaASdKboknIxpBRxtB4QqFkkZP4nlCVHK-NZnR_Xgt9I2Dfh_IoK</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3084950619</pqid></control><display><type>article</type><title>An Overview of Methotrexate Indications in Skin Diseases</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Mocanu, Mădălina ; Procopciuc, Dorina ; Gheucă-Solovăstru, Dragoș-Florin ; Popescu, Ioana Adriana ; Olinici, Doinița Temelie ; Pătrașcu, Adriana Ionela ; Vâță, Dan ; Gheucă-Solovăstru, Laura</creator><creatorcontrib>Mocanu, Mădălina ; Procopciuc, Dorina ; Gheucă-Solovăstru, Dragoș-Florin ; Popescu, Ioana Adriana ; Olinici, Doinița Temelie ; Pătrașcu, Adriana Ionela ; Vâță, Dan ; Gheucă-Solovăstru, Laura</creatorcontrib><description>Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.</description><identifier>ISSN: 1648-9144</identifier><identifier>ISSN: 1010-660X</identifier><identifier>EISSN: 1648-9144</identifier><identifier>DOI: 10.3390/medicina60071024</identifier><identifier>PMID: 39064453</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine ; Bioavailability ; Caffeine ; Cytokines ; Dermatologic Agents - pharmacology ; Dermatologic Agents - therapeutic use ; Dihydrofolate reductase ; Enzymes ; Fibroblasts ; Gene expression ; Humans ; Immunosuppressive Agents - therapeutic use ; Lymphocytes ; methotrexate ; Methotrexate - therapeutic use ; Neutrophils ; off-label indications ; Oral administration ; Physiology ; Psoriasis ; Psoriasis - drug therapy ; Rheumatoid arthritis ; Skin diseases ; Skin Diseases - drug therapy ; Toxicity ; Vitamin B</subject><ispartof>Medicina (Kaunas, Lithuania), 2024-06, Vol.60 (7), p.1024</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0447-3625 ; 0000-0002-2755-6004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3084950619/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3084950619?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25752,27923,27924,37011,37012,44589,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39064453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mocanu, Mădălina</creatorcontrib><creatorcontrib>Procopciuc, Dorina</creatorcontrib><creatorcontrib>Gheucă-Solovăstru, Dragoș-Florin</creatorcontrib><creatorcontrib>Popescu, Ioana Adriana</creatorcontrib><creatorcontrib>Olinici, Doinița Temelie</creatorcontrib><creatorcontrib>Pătrașcu, Adriana Ionela</creatorcontrib><creatorcontrib>Vâță, Dan</creatorcontrib><creatorcontrib>Gheucă-Solovăstru, Laura</creatorcontrib><title>An Overview of Methotrexate Indications in Skin Diseases</title><title>Medicina (Kaunas, Lithuania)</title><addtitle>Medicina (Kaunas)</addtitle><description>Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.</description><subject>Adenosine</subject><subject>Bioavailability</subject><subject>Caffeine</subject><subject>Cytokines</subject><subject>Dermatologic Agents - pharmacology</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dihydrofolate reductase</subject><subject>Enzymes</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Lymphocytes</subject><subject>methotrexate</subject><subject>Methotrexate - therapeutic use</subject><subject>Neutrophils</subject><subject>off-label indications</subject><subject>Oral administration</subject><subject>Physiology</subject><subject>Psoriasis</subject><subject>Psoriasis - drug therapy</subject><subject>Rheumatoid arthritis</subject><subject>Skin diseases</subject><subject>Skin Diseases - drug therapy</subject><subject>Toxicity</subject><subject>Vitamin B</subject><issn>1648-9144</issn><issn>1010-660X</issn><issn>1648-9144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkUtPAyEUhYnRWF97V2YSN26q3OExsDQ-m2i6UNeEYW6V2g4K06r_XmprYwwJ3MB3zr3kEHII9JQxTc-m2HjnWysprYCWfIPsgOSqr4HzzT91j-ymNKaUlaIqt0kvayXngu0Qdd4WwznGucePIoyKe-xeQhfx03ZYDNpsbzsf2lT4tnh4zdulT2gTpn2yNbKThAerc488XV89Xtz274Y3g4vzu75joLp-WVohgQsN4LRlpYa6os45WsmRoELnCRk4ViqtNMimZCovELW1umqUcmyPDJa-TbBj8xb91MYvE6w3PxchPhsbO-8maETTNLZGWYEDrmpZc8xdeG4BNXcMs9fJ0usthvcZps5MfXI4mdgWwywZRpUA0FyzjB7_Q8dhFtv80wXFtaASdKboknIxpBRxtB4QqFkkZP4nlCVHK-NZnR_Xgt9I2Dfh_IoK</recordid><startdate>20240621</startdate><enddate>20240621</enddate><creator>Mocanu, Mădălina</creator><creator>Procopciuc, Dorina</creator><creator>Gheucă-Solovăstru, Dragoș-Florin</creator><creator>Popescu, Ioana Adriana</creator><creator>Olinici, Doinița Temelie</creator><creator>Pătrașcu, Adriana Ionela</creator><creator>Vâță, Dan</creator><creator>Gheucă-Solovăstru, Laura</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0447-3625</orcidid><orcidid>https://orcid.org/0000-0002-2755-6004</orcidid></search><sort><creationdate>20240621</creationdate><title>An Overview of Methotrexate Indications in Skin Diseases</title><author>Mocanu, Mădălina ; Procopciuc, Dorina ; Gheucă-Solovăstru, Dragoș-Florin ; Popescu, Ioana Adriana ; Olinici, Doinița Temelie ; Pătrașcu, Adriana Ionela ; Vâță, Dan ; Gheucă-Solovăstru, Laura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-22a56145911c9a3291b70ccc076f505964831c32898916d23838315baa97d88c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adenosine</topic><topic>Bioavailability</topic><topic>Caffeine</topic><topic>Cytokines</topic><topic>Dermatologic Agents - pharmacology</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dihydrofolate reductase</topic><topic>Enzymes</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Lymphocytes</topic><topic>methotrexate</topic><topic>Methotrexate - therapeutic use</topic><topic>Neutrophils</topic><topic>off-label indications</topic><topic>Oral administration</topic><topic>Physiology</topic><topic>Psoriasis</topic><topic>Psoriasis - drug therapy</topic><topic>Rheumatoid arthritis</topic><topic>Skin diseases</topic><topic>Skin Diseases - drug therapy</topic><topic>Toxicity</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mocanu, Mădălina</creatorcontrib><creatorcontrib>Procopciuc, Dorina</creatorcontrib><creatorcontrib>Gheucă-Solovăstru, Dragoș-Florin</creatorcontrib><creatorcontrib>Popescu, Ioana Adriana</creatorcontrib><creatorcontrib>Olinici, Doinița Temelie</creatorcontrib><creatorcontrib>Pătrașcu, Adriana Ionela</creatorcontrib><creatorcontrib>Vâță, Dan</creatorcontrib><creatorcontrib>Gheucă-Solovăstru, Laura</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Medicina (Kaunas, Lithuania)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mocanu, Mădălina</au><au>Procopciuc, Dorina</au><au>Gheucă-Solovăstru, Dragoș-Florin</au><au>Popescu, Ioana Adriana</au><au>Olinici, Doinița Temelie</au><au>Pătrașcu, Adriana Ionela</au><au>Vâță, Dan</au><au>Gheucă-Solovăstru, Laura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Overview of Methotrexate Indications in Skin Diseases</atitle><jtitle>Medicina (Kaunas, Lithuania)</jtitle><addtitle>Medicina (Kaunas)</addtitle><date>2024-06-21</date><risdate>2024</risdate><volume>60</volume><issue>7</issue><spage>1024</spage><pages>1024-</pages><issn>1648-9144</issn><issn>1010-660X</issn><eissn>1648-9144</eissn><abstract>Methotrexate is an immunosuppressive drug with remarkable therapeutic results in the treatment of autoimmune and proliferative skin diseases. Although it has been more than half a century since it was first introduced into the therapeutic arsenal of dermatologists, there are currently no standardized therapeutic protocols regarding the prescription of methotrexate in dermatology, with the exception of psoriasis treatment. This review aims to highlight the indications and benefits of methotrexate beyond psoriasis, with a focus on a wide range of inflammatory, vesiculobullous, and proliferative dermatological pathologies.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39064453</pmid><doi>10.3390/medicina60071024</doi><orcidid>https://orcid.org/0000-0003-0447-3625</orcidid><orcidid>https://orcid.org/0000-0002-2755-6004</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1648-9144 |
| ispartof | Medicina (Kaunas, Lithuania), 2024-06, Vol.60 (7), p.1024 |
| issn | 1648-9144 1010-660X 1648-9144 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_5dddabe671c148b6b4e76f46481b4c3e |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adenosine Bioavailability Caffeine Cytokines Dermatologic Agents - pharmacology Dermatologic Agents - therapeutic use Dihydrofolate reductase Enzymes Fibroblasts Gene expression Humans Immunosuppressive Agents - therapeutic use Lymphocytes methotrexate Methotrexate - therapeutic use Neutrophils off-label indications Oral administration Physiology Psoriasis Psoriasis - drug therapy Rheumatoid arthritis Skin diseases Skin Diseases - drug therapy Toxicity Vitamin B |
| title | An Overview of Methotrexate Indications in Skin Diseases |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T07%3A24%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Overview%20of%20Methotrexate%20Indications%20in%20Skin%20Diseases&rft.jtitle=Medicina%20(Kaunas,%20Lithuania)&rft.au=Mocanu,%20M%C4%83d%C4%83lina&rft.date=2024-06-21&rft.volume=60&rft.issue=7&rft.spage=1024&rft.pages=1024-&rft.issn=1648-9144&rft.eissn=1648-9144&rft_id=info:doi/10.3390/medicina60071024&rft_dat=%3Cproquest_doaj_%3E3084950619%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c318t-22a56145911c9a3291b70ccc076f505964831c32898916d23838315baa97d88c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3084950619&rft_id=info:pmid/39064453&rfr_iscdi=true |