Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is s...

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Bibliographic Details
Published in:Life (Basel, Switzerland) Switzerland), 2023-03, Vol.13 (4), p.903
Main Authors: Shtykalova, Sofia, Deviatkin, Dmitriy, Freund, Svetlana, Egorova, Anna, Kiselev, Anton
Format: Article
Language:English
Subjects:
Acids
Analysis
Complications and side effects
Cytotoxicity
Deoxyribonucleic acid
DNA
endocytosis
gene delivery
Gene therapy
Gene transfer
Genes
Health aspects
Heparan sulfate
Immunogenicity
liposomes
Molecular weight
Nanoparticles
non-viral carriers
Nucleic acids
Patient outcomes
peptide-based carriers
Peptides
Polymers
polyplexes
Proteins
Review
Ribonucleic acid
RNA
Surface charge
Toxicity
Viruses
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Summary:Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13040903