Circadian Oscillations of Minimal Erythema Dose (MED) are Also Influenced by Diet in Patients with Psoriasis: A Chronomedical Study

Introduction Minimal erythema dose (MED) remains a parameter of paramount importance to orient narrow-band (NB)-UVB phototherapy in psoriatic (PsO) patients. Recently, circadian rhythm and diet were recognized as potential MED modulators, but their mutual interaction remains understudied. Thus, we a...

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Published in:Dermatology and therapy 2023-10, Vol.13 (10), p.2229-2246
Main Authors: Damiani, Giovanni, Pacifico, Alessia, Scoditti, Egeria, di Gregorio, Sara, Del Fabbro, Massimo, Cozzolino, Claudia, Buja, Alessandra, Mercuri, Santo R., Bianchi, Vittoria G., Grada, Ayman, Garbarino, Sergio, Bunick, Christopher G.
Format: Article
Language:English
Subjects:
Care and treatment
Circadian rhythm
Circadian rhythms
Dermatology
Diet
Erythema
Fasting
Health aspects
Internal Medicine
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Minimal erythema dose (MED)
Narrow-band-UVB (NB-UVB)
Oral and Maxillofacial Surgery
Original Research
Phototherapy
Physiological aspects
Plastic Surgery
Psoriasis
Quality of Life Research
Skin
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Summary:Introduction Minimal erythema dose (MED) remains a parameter of paramount importance to orient narrow-band (NB)-UVB phototherapy in psoriatic (PsO) patients. Recently, circadian rhythm and diet were recognized as potential MED modulators, but their mutual interaction remains understudied. Thus, we aimed to evaluate the potential diet modulation of MED circadian oscillations. Methods In the first phase, a cohort study was performed comparing potential MED oscillations (morning, afternoon, and evening) among omnivorous psoriatic patients before and after a phototherapy cycle and omnivorous healthy controls. The two groups were age-, gender-, skin-type-, MED-, and diet-matched. Then, in the second phase, another cohort study was carried out comparing MED oscillations 24 h after the last phototherapeutic session only in psoriatic patients cleared with NB-UVB and undergoing different diets (vegan, vegetarian, paleo , ketogenic, intermittent circadian fasting, and omnivore). Patients with different diets were age-, gender-, and skin-type matched. Results In the first phase, we enrolled only omnivores, specifically 54 PsO patients and 54 healthy individuals. Their MED before and after NB-UVB therapy changed significantly among the three different time-points (morning, afternoon, and evening) ( p  
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-023-00987-z