Pemphigus foliaceus with pustular presentation in a patient with psoriasis

Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils,...

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Published in:Anais brasileiros de dermatología 2017, Vol.92 (5 Suppl 1), p.115-117
Main Authors: Sousa, Vando Barbosa de, Santana, Cândida Naira Lima E Lima, Pereira, Daniele do Nascimento, Gripp, Alexandre Carlos
Format: Article
Language:English
Subjects:
Biopsy
Case Report
DERMATOLOGY
Dose-Response Relationship, Drug
Erythema - pathology
Glucocorticoids - therapeutic use
Humans
Male
Middle Aged
Pemphigus
Pemphigus - drug therapy
Pemphigus - etiology
Pemphigus - pathology
Prednisone - therapeutic use
Psoriasis
Psoriasis - complications
Psoriasis - drug therapy
Psoriasis - pathology
Skin - pathology
Vesiculobullous conditions
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Summary:Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. We report the case of a 55-year-old man with a history of psoriasis vulgaris that has developed pemphigus foliaceus with pustules, triggered by withdrawal of systemic corticosteroids. This is the first report associating this atypical form of pemphigus with psoriasis, suggesting that an overlap with generalized pustular psoriasis can occur.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1590/abd1806-4841.20175709