Effectiveness of date seed on glycemia and advanced glycation end-products in type 2 diabetes: a randomized placebo-controlled trial

Background Type 2 diabetes mellitus (T2DM) is a chronic medical condition affecting more than 95% of people with diabetes. Traditionally, some medicinal plants have been considered as an effective approach in management of T2DM. This trial evaluated the effects of date seed powder (DSP) on glycemia...

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Bibliographic Details
Published in:Nutrition & diabetes 2024-06, Vol.14 (1), p.37-9, Article 37
Main Authors: Mohamadizadeh, Mehdi, Dehghan, Parvin, Azizi-Soleiman, Fatemeh, Maleki, Parham
Format: Article
Language:English
Subjects:
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Adult
Aged
Analysis of covariance
Blood Glucose - drug effects
Clinical Nutrition
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Epidemiology
Female
Glycated Hemoglobin - analysis
Glycation End Products, Advanced - blood
Glycemic Index - drug effects
Humans
Insulin - blood
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Receptor for Advanced Glycation End Products - blood
Seeds
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Summary:Background Type 2 diabetes mellitus (T2DM) is a chronic medical condition affecting more than 95% of people with diabetes. Traditionally, some medicinal plants have been considered as an effective approach in management of T2DM. This trial evaluated the effects of date seed powder (DSP) on glycemia indices and oxidative stress in T2DM patients. Methods In this trail, 43 patients with T2DM were randomized to two groups: either 5 g/d of the DSP or placebo for 8 weeks. Levels of glycemic indices, lipolpolysaccharide (LPS), and soluble receptor for advanced glycation end products (s-RAGE), as well as other parameters associated with oxidative stress were assessed at baseline and after 8 weeks. Independent t-test and analysis of covariance (ANCOVA) were used for between-groups comparisons at baseline and the post-intervention phase, respectively. Results The results showed that supplementation with DSP significantly decreased HbA1c (−0.30 ± 0.48%), insulin (−1.70 ± 2.21 μU/ml), HOMA-IR (−1.05 ± 0.21), HOMA-B (−0.76 ± 21.21), lipopolysaccharide (LPS) (−3.68 ± 6.05 EU/mL), and pentosidine (118.99 ± 21.67 pg/mL) ( P  
ISSN:2044-4052
2044-4052
DOI:10.1038/s41387-024-00287-1