Actinoflavosides B–D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces

Three new secondary metabolites, actinoflavosides B–D (1–3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR...

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Bibliographic Details
Published in:Marine drugs 2022-09, Vol.20 (9), p.565
Main Authors: Jeong, Hyeongju, Jo, Se, Bae, Munhyung, Kim, Young, Moon, Kyuho
Format: Article
Language:English
Subjects:
actinoflavoside
antibacterial
Antibacterial activity
Antibiotics
Cell growth
Chromatography
Connectivity
Cytokines
flavonoid
Flavonoids
Glycosides
Interleukin 2
Lymphocytes
Mass spectrometry
Metabolites
Microorganisms
Mud flats
Natural products
NMR
Nuclear magnetic resonance
Planar structures
Pseudomonas aeruginosa
Scientific imaging
secondary metabolite
Secondary metabolites
Splenocytes
Stereochemistry
structural determination
tidal mudflat
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Summary:Three new secondary metabolites, actinoflavosides B–D (1–3), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by J-based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher’s method. Actinoflavosides B–D (1–3) displayed antibacterial activity against Pseudomonas aeruginosa, and actinoflavoside D (3) significantly increased IL-2 production in mouse splenocytes.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20090565