Novel Models of Crohn's Disease Pathogenesis Associated with the Occurrence of Mitochondrial Dysfunction in Intestinal Cells

Crohn's disease remains one of the challenging problems of modern medicine, and the development of new and effective and safer treatments against it is a dynamic field of research. To make such developments possible, it is important to understand the pathologic processes underlying the onset an...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (9), p.5141
Main Authors: Blagov, Alexander, Zhigmitova, Elena B, Sazonova, Margarita A, Mikhaleva, Liudmila M, Kalmykov, Vladislav, Shakhpazyan, Nikolay K, Orekhova, Varvara A, Orekhov, Alexander N
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Carbohydrates
Chronic illnesses
Crohn Disease - therapy
Crohn's disease
Diet
Digestive system
Gene expression
Health risk assessment
Humans
Hypotheses
Industrialized nations
Inflammation
Intestines
Medical research
Microbiota
Mitochondria
mitochondrion
Mutation
Nonsteroidal anti-inflammatory drugs
Nutrition research
Pathogenesis
Permeability
Remission (Medicine)
Review
Smoking
Womens health
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Summary:Crohn's disease remains one of the challenging problems of modern medicine, and the development of new and effective and safer treatments against it is a dynamic field of research. To make such developments possible, it is important to understand the pathologic processes underlying the onset and progression of Crohn's disease at the molecular and cellular levels. During the recent years, the involvement of mitochondrial dysfunction and associated chronic inflammation in these processes became evident. In this review, we discuss the published works on pathogenetic models of Crohn's disease. These models make studying the role of mitochondrial dysfunction in the disease pathogenesis possible and advances the development of novel therapies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23095141