The Therapeutic Potential of Agarwood as an Antimicrobial and Anti-Inflammatory Agent: A Scoping Review

• Published in: Antibiotics (Basel) 2024-11, Vol.13 (11), p.1074
• Main Authors: Abd Rashed, Aswir, Jamilan, Mohd Azerulazree, Abdul Rahman, Salina, Amin Nordin, Fatimah Diana, Mohd Nawi, Mohd Naeem
• Format: Article
• Language: English
• Subjects: Amino acids; Anti-infective agents; anti-inflammatory; Anti-inflammatory agents; Anti-inflammatory drugs; Antibiotics; antimicrobial; Antimicrobial agents; Antiviral agents; Aquilaria spp; B cells; Bacteria; Care and treatment; Clinical trials; Composition; Dilleniidae; Effectiveness; Enzymes; Ethanol; Fungi; Fusarium oxysporum; Gram-negative bacteria; Health aspects; Herbal medicine; Immune system; Inflammation; Irritation; Kinases; Medical research; Medicine, Botanic; Medicine, Herbal; Microorganisms; NF-κB protein; Oxidative stress; Pharmacology; Plantations; Review; Reviews; Superoxide anions; Testing
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics13111074

Microorganisms such as bacteria, viruses, and fungi are frequently the cause of infections. Antimicrobial agents, such as antibiotics, antivirals, and antifungals, are used to target and eliminate these infectious agents. On the other hand, inflammation is a natural response of the immune system to injury, infection, or irritation. Although herbal remedies have been used to treat these conditions for centuries and can be effective in certain situations, it is crucial to use them with caution. Not all herbal remedies are supported by scientific evidence, and their safety and efficacy can vary. Thus, we conducted this review to determine the potential health benefits of agarwood as an antimicrobial and anti-inflammatory agent. Three databases (PubMed, Scopus, and Google Scholar) were used to search for original papers submitted between 2013 and 2023, using the Medical Subject Heading (MeSH) terms "agar-wood" crossed with the terms "antimicrobial" and/or "anti-inflammatory". Synonyms and relevant search terms were also searched. The most-studied agarwood for antimicrobial and anti-inflammatory agents is . Some studies have shown its potential application as a potent inhibitor of fungi, including , , and . Moreover, it is capable of inhibiting and activities. Several chromones detected in agarwood have been shown to inhibit NF-κB activation, LPS-induced NO production, and superoxide anion generation. In conclusion, more research is needed, particularly regarding future intervention studies, to enhance our knowledge and understanding of agarwood and its isolates. This review reveals that despite the absence of clinical trials, agarwood exhibits antimicrobial and anti-inflammatory properties.