Expansion of Shiga Toxin-Producing Escherichia coli by Use of Bovine Antibiotic Growth Promoters

Antibiotics are routinely used in food-producing animals to promote growth and prevent infectious diseases. We investigated the effects of bovine antibiotic growth promoters (bAGPs) on the propagation and spread of Shiga toxin (Stx)-encoding phages in Escherichia coli. Co-culture of E. coli O157:H7...

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Bibliographic Details
Published in:Emerging infectious diseases 2016-05, Vol.22 (5), p.802-809
Main Authors: Kim, Jong-Chul, Chui, Linda, Wang, Yang, Shen, Jianzhong, Jeon, Byeonghwa
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
antibiotic growth promoters
bacteria
Bacteriophages
Bacteriophages - physiology
by Use of Bovine Antibiotic Growth Promoters
Care and treatment
Cattle
Communicable diseases
E. coli
Escherichia coli
Escherichia coli Infections - microbiology
Expansion of Shiga Toxin–Producing
Growth
Health aspects
Properties
Shiga Toxin - biosynthesis
Shiga toxin–producing Escherichia coli
Shiga-Toxigenic Escherichia coli - drug effects
Shiga-Toxigenic Escherichia coli - metabolism
Shiga-Toxigenic Escherichia coli - virology
STEC
Stx-encoding bacteriophages
Transduction, Genetic
Virus Replication
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Summary:Antibiotics are routinely used in food-producing animals to promote growth and prevent infectious diseases. We investigated the effects of bovine antibiotic growth promoters (bAGPs) on the propagation and spread of Shiga toxin (Stx)-encoding phages in Escherichia coli. Co-culture of E. coli O157:H7 and other E. coli isolated from cattle in the presence of sublethal concentrations of bAGPs significantly increased the emergence of non-O157, Stx-producing E. coli by triggering the SOS response system in E. coli O157:H7. The most substantial mediation of Stx phage transmission was induced by oxytetracyline and chlortetracycline, which are commonly used in agriculture. bAGPs may therefore contribute to the expansion of pathogenic Stx-producing E. coli.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2205.151584