Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants u...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2272-2272, Article 2272
Main Authors: Yokota, Takashi, Kinugawa, Shintaro, Hirabayashi, Kagami, Yamato, Mayumi, Takada, Shingo, Suga, Tadashi, Nakano, Ippei, Fukushima, Arata, Matsushima, Shouji, Okita, Koichi, Tsutsui, Hiroyuki
Format: Article
Language:English
Subjects:
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Aerobic capacity
Anaerobic threshold
Antioxidants
Congestive heart failure
Energy metabolism
Exercise
Heart failure
Humanities and Social Sciences
Intolerance
Magnetic resonance spectroscopy
Metabolism
multidisciplinary
Musculoskeletal system
Oxidative stress
Oxygen uptake
Phosphocreatine
Physical fitness
Plantar flexion
Science
Science (multidisciplinary)
Skeletal muscle
Superoxide dismutase
Thiobarbituric acid
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Summary:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81736-0