Vitamin D plasma concentration and vitamin D receptor genetic variants confer risk of asthma: A comparison study of Taiwanese and Mongolian populations

Recent reports have suggested that lower vitamin D serum levels are associated with susceptibility to and severity of asthma in different white populations, which may be due to a lack of sunlight exposure, genetic polymorphism of vitamin D pathway genes, and dietary intake. We investigated the assoc...

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Bibliographic Details
Published in:The World Allergy Organization journal 2019-11, Vol.12 (11), p.100076-100076, Article 100076
Main Authors: Munkhbayarlakh, Sonomjamts, Kao, Hui-Fang, Hou, Yung-I., Tuvshintur, Naidansuren, Bayar-Ulzii, Batmunkh, Narantsetseg, Logii, Wang, Jiu Yao, Hsin Wu, Lawrence Shih
Format: Article
Language:English
Subjects:
Allergens
Allergies
Asthma
Genotype & phenotype
Ions
Minority & ethnic groups
Regression analysis
Single-nucleotide polymorphism
Skin
Statistical analysis
Vitamin D
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Summary:Recent reports have suggested that lower vitamin D serum levels are associated with susceptibility to and severity of asthma in different white populations, which may be due to a lack of sunlight exposure, genetic polymorphism of vitamin D pathway genes, and dietary intake. We investigated the associations between vitamin D concentration, genetic polymorphism of the vitamin D receptor (VDR), and asthma traits in Mongolian and Taiwanese populations that inhabited two different geographical areas. In total, 328 Han Taiwanese subjects and 381 Mongolian subjects were enrolled, and their vitamin D serum levels assayed. Genomic DNA of 178 Han Taiwanese subjects and 90 Mongolian subjects was obtained from blood samples. Single-nucleotide polymorphisms (SNPs) of VDR, ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410) and FokI (rs2228570), were selected for genotyping. Logistic regression analyses were performed to detect an association between allergic asthma status and the interaction of the VDR SNP and serum vitamin D concentration in the case–control samples. We observed a significantly lower vitamin D level in the Mongolian subjects as compared with the Taiwanese population. In particular, in the population under 14 years of age, the serum vitamin D level was significantly higher in the Taiwanese population, in both non-asthmatic and asthmatic subjects, than in the Mongolian non-asthmatic and asthmatic subjects, respectively (P 
ISSN:1939-4551
1939-4551
DOI:10.1016/j.waojou.2019.100076