Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group

Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications...

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Bibliographic Details
Published in:Frontiers in oncology 2022-04, Vol.12, p.805613-805613
Main Authors: Zannoni, Gian Franco, Bragantini, Emma, Castiglione, Francesca, Fassan, Matteo, Troncone, Giancarlo, Inzani, Frediano, Pesci, Anna, Santoro, Angela, Fraggetta, Filippo
Format: Article
Language:English
Subjects:
endometrial cancer
histomolecular classification
Oncology
pathological guidelines
prognostic markers
prognostic stratification
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Summary:Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.805613