Mechanisms of HIV-immunologic non-responses and research trends based on gut microbiota

With the increasing number of people with HIV (PWH) and the use of antiretroviral treatment (ART) for PWH, HIV has gradually become a chronic infectious disease. However, some infected individuals develop issues with immunologic non-responses (INRs) after receiving ART, which can lead to secondary i...

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Bibliographic Details
Published in:Frontiers in immunology 2024-12, Vol.15
Main Authors: Sun, Xiangbin, Xie, Zhanpeng, Wu, Zhen, Song, Meiyang, Zhang, Youxian, Zhang, Zezhan, Cui, Xinxin, Liu, Aodi, Li, Ke
Format: Article
Language:English
Subjects:
gut microbiota
HIV/AIDS
INRs
traditional Chinese medicine (TCM)
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Summary:With the increasing number of people with HIV (PWH) and the use of antiretroviral treatment (ART) for PWH, HIV has gradually become a chronic infectious disease. However, some infected individuals develop issues with immunologic non-responses (INRs) after receiving ART, which can lead to secondary infections and seriously affect the life expectancy and quality of life of PWH. Disruption of the gut microbiota is an important factor in immune activation and inflammation in HIV/AIDS, thus stabilizing the gut microbiota to reduce immune activation and inflammation and promoting immune reconstitution may become a direction for the treatment of HIV/AIDS. This paper, based on extensive literature review, summarizes the definition, mechanisms, and solutions for INRs, starting from the perspective of gut microbiota.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1378431