Association between albumin and depression: a population-based study

Introduction Albumin is the most prevalent plasma protein and is involved in a variety of critical physiological processes. Low serum albumin levels have been linked to depression symptoms in people who had recent suicide attempts and those suffering from several mental diseases such as acute episod...

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Bibliographic Details
Published in:BMC psychiatry 2023-10, Vol.23 (1), p.1-780, Article 780
Main Authors: Al-Marwani, Sabah, Batieha, Anwar, Khader, Yousef, El-Khateeb, Mohammed, Jaddou, Hashem, Ajlouni, Kamel
Format: Article
Language:English
Subjects:
Affective disorders
Albumin
Analysis
Blood proteins
Body mass index
Calcium (blood)
Calcium phosphates
Care and treatment
Chronic illnesses
Comorbidity
Data analysis
Depression
Depression, Mental
Diabetes
Diagnosis
Dietary minerals
Education
Endocrinology
Health aspects
Health surveys
Jordan
Laboratories
Liver diseases
Magnesium
Marital status
Measurement
Mental depression
Mental disorders
Mood disorders
National survey
Nutrition
Phosphates
Population studies
Prevention
Psychiatric disorders
Psychiatry
Quantitative psychology
Questionnaires
Regression analysis
Sample size
Schizophrenia
Serum albumin
Statistical analysis
Suicidal behavior
Suicide
Suicides & suicide attempts
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Summary:Introduction Albumin is the most prevalent plasma protein and is involved in a variety of critical physiological processes. Low serum albumin levels have been linked to depression symptoms in people who had recent suicide attempts and those suffering from several mental diseases such as acute episodes of mania, and schizophrenia. However, there has been little investigation into the relationship between depression and serum albumin levels in community-dwelling persons. This research aimed to examine the relationship between serum albumin and depression in a population-based sample and whether it differs depending on other possible confounders. Methods Our data were derived from a national household population study conducted in 2017 with a sample size of 3,521 Jordanians aged > 17 years old. The Patient Health Questionnaire (PHQ-9) scale, a self-administered scale, was used to screen for depression. Concentrations of serum albumin and other medical biomarkers were measured by blood tests. Using descriptive statistics for depression distribution and multivariate logistic regression analysis, the connection between albumin levels and depression was investigated. Results The odds ratios (ORs) for depression were significantly lower in the third and fourth quartiles of serum albumin concentration compared to the first quartile (OR = 0.64 and 0.66, respectively; P values =
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-023-05174-0