Sudden Unexpected Postnatal Collapse and Therapeutic Hypothermia: What's Going On?

Sudden unexpected postnatal collapse (SUPC) is a rare event, potentially associated with catastrophic consequences. Since the beginning of the 2000s, therapeutic hypothermia (TH) has been proposed as a treatment for asphyxiated neonates after SUPC. However, only a few studies have reported the outco...

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Published in:Children (Basel) 2022-12, Vol.9 (12), p.1925
Main Authors: Bedetti, Luca, Lugli, Licia, Garetti, Elisabetta, Guidotti, Isotta, Roversi, Maria Federica, Della Casa, Elisa, Miselli, Francesca, Bariola, Maria Carolina, Di Caprio, Antonella, Pugliese, Marisa, Ferrari, Fabrizio, Berardi, Alberto
Format: Article
Language:English
Subjects:
Asphyxia neonatorum
Births
brain cooling
Cerebral palsy
Clinical trials
Hypothermia
Intensive care
Metabolism
neurodevelopmental outcome
Newborn babies
Pediatrics
Physiological aspects
sudden unexpected postnatal collapse
therapeutic hypothermia
Ventilators
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Summary:Sudden unexpected postnatal collapse (SUPC) is a rare event, potentially associated with catastrophic consequences. Since the beginning of the 2000s, therapeutic hypothermia (TH) has been proposed as a treatment for asphyxiated neonates after SUPC. However, only a few studies have reported the outcome of SUPC after TH. The current study presents the long-term neurodevelopmental outcome of four cases of SUPC treated with TH in a single Italian center. Furthermore, we reviewed the previous literature concerning 49 cases of SUPC treated with TH. Among 53 total cases (of whom four occurred in our center), 15 (28.3%) died before discharge from the NICU. A neurodevelopmental follow-up was available only for 21 (55.3%) out of the 38 surviving cases, and seven infants developed neurodevelopmental sequelae. TH should be considered in neonates with asphyxia after SUPC. However, SUPC is a rare event, and there is a lack of comparative clinical data to establish the risk/benefit of TH after SUPC with different degrees of asphyxia. Analysis of large cohorts of newborns with SUPC, whether treated with TH or untreated, are needed in order to better identify infants who should undergo TH.
ISSN:2227-9067
2227-9067
DOI:10.3390/children9121925