Intraoperative Indocyanine Green Retention Test of Left Hemiliver in Decision-Making for Patients With Hepatocellular Carcinoma Undergoing Right Hepatectomy

• Published in: Frontiers in surgery 2021-09, Vol.8, p.709017-709017
• Main Authors: Yu, Tingdong, Ye, Xinping, Wen, Zhang, Zhu, Guangzhi, Su, Hao, Han, Chuangye, Huang, Ketuan, Qin, Wei, Liao, Xiwen, Yang, Chengkun, Liu, Zhen, Wang, Xiangkun, Xu, Banghao, Su, Ming, Lv, Zili, Lau, Wan Yee, Peng, Tao
• Format: Article
• Language: English
• Subjects: ALPPS; future liver remnant; hepatectomy; hepatocellular carcinoma; indocyanine green retention test; portal vein ligation; Surgery
• ISSN: 2296-875X; 2296-875X
• DOI: 10.3389/fsurg.2021.709017

Introduction: The aim of this study was to select qualified patients with hepatocellular carcinoma (HCC) who underwent right hepatectomy (RH) via intraoperative indocyanine green retention test at 15 min (ICG-R15) of the left hemiliver, which prevents severe posthepatectomy liver failure (PHLF). Methods: Twenty HCC patients who were preoperatively planned to undergo RH were enrolled. Intraoperative ICG-R15 of left hemiliver was measured after the right Glissonean pedicle was completely blocked. Patients then underwent RH if intraoperative ICG-R15 was ≤ 10%. Otherwise, patients underwent staged RH (SRH), either associating liver partitioning and portal vein ligation for staged hepatectomy (ALPPS) or portal vein ligation (PVL), followed by stage-2 RH. The comparison group consisted of patients with a ratio of standard left liver volume (SLLV) of > 40% and preoperative ICG-R15 ≤ 10% who underwent RH. The clinical outcomes of these two groups were compared. Results: Of the 20 patients, six underwent stage-1 RH, six underwent ALPPS, five underwent PVL followed by stage-2 RH, and three failed to proceed to stage-2 RH after PVL. No significant differences were found among the 17 patients who underwent stage-1 or stage-2 RH in the study group, the 19 patients in the comparison group, the 11 patients in the stage-2 RH group, and the six patients in the stage-1 RH group in incidences of PHLF, postoperative complications, hospital stay, and HCC recurrence within 1 year after RH. Compared with the stage-1 ALPPS group, the mean operative time and blood loss of the stage-1 PVL group were significantly less ( p