Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic Foot Ulcer Infections

Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new trea...

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Bibliographic Details
Published in:Gels 2023-03, Vol.9 (3), p.262
Main Authors: Chijcheapaza-Flores, Henry, Tabary, Nicolas, Chai, Feng, Maton, Mickaël, Staelens, Jean-Noel, Cazaux, Frédéric, Neut, Christel, Martel, Bernard, Blanchemain, Nicolas, Garcia-Fernandez, Maria José
Format: Article
Language:English
Subjects:
Aldehydes
Antibiotics
antimicrobial treatment
Bacteria
Biofilms
Chemical Sciences
Chitosan
Cinnamaldehyde
Cyclodextrins
Debridement
Diabetes
Diabetic foot
diabetic foot ulcers
Diabetics
drug delivery
Drug delivery systems
Drug resistance in microorganisms
Drug therapy
Drugs
Foot diseases
Health aspects
Hydrogels
Imines
Infection
Leg ulcers
Material chemistry
Mechanical properties
NMR
Nuclear magnetic resonance
Polymers
Ulcers
Vehicles
Viscoelasticity
Viscosity
Wound healing
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Summary:Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new treatment option since they can be used for drug delivery and to improve wound healing. This project aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of β cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. This work consisted of the development and characterisation of the hydrogel, the evaluation of the CN release kinetics and cell viability (on a MC3T3 pre-osteoblast cell line), and the evaluation of the antimicrobial and antibiofilm activity ( and ). The results demonstrated the successful development of a cytocompatible (ISO 10993-5) injectable hydrogel with antibacterial (99.99% bacterial reduction) and antibiofilm activity. Furthermore, a partial active molecule release and an increase in hydrogel elasticity were observed in the presence of CN. This leads us to hypothesise that a reaction between CHT and CN (a Schiff base) can occur and that CN could act as a physical crosslinker, thus improving the viscoelastic properties of the hydrogel and limiting CN release.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9030262