Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in processes related to tumour initiation...

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Bibliographic Details
Published in:Biomarker research 2022-07, Vol.10 (1), p.1-52, Article 52
Main Authors: LI, Hai-Long, Deng, Nian-Hua, He, Xiu-Sheng, Li, Yue-Hua
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Angiogenesis
Apoptosis
Autophagy
Biological markers
Biomarkers
Biosynthesis
Cancer
Carcinoma
Cell cycle
Cell growth
Chemotherapy
Drug resistance
Gene expression
Growth factors
Kinases
Medical prognosis
Metabolism
Metastases
Metastasis
MicroRNA
MicroRNAs
miRNA
miRNAs
Mutation
Nasopharyngeal carcinoma
PI3K/AKT/mTOR
Proteins
Radiation therapy
Rapamycin
Review
Signal transduction
Therapeutic targets
TOR protein
Tumorigenesis
Tumors
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Summary:Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in processes related to tumour initiation/progression, such as proliferation, apoptosis, metastasis, and drug resistance, and is closely related to the clinicopathological features of NPC. In addition, key genes involved in the PI3K/AKT/mTOR signalling pathway undergo many changes in NPC. More interestingly, a growing body of evidence suggests an interaction between this signalling pathway and microRNAs (miRNAs), a class of small noncoding RNAs. Therefore, in this review, we discuss the interactions between key components of the PI3K/AKT/mTOR signalling pathway and various miRNAs and their importance in NPC pathology and explore potential diagnostic biomarkers and therapeutic targets.
ISSN:2050-7771
2050-7771
DOI:10.1186/s40364-022-00397-x