The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex

As a novel type of non-coding RNA, circular RNAs (circRNAs) play a critical role in the initiation and development of various diseases, including cancer. However, the exact function of circRNAs in human cervical cancer remains largely unknown. We identified the circRNA signature of upregulated circR...

Full description

Saved in:
Bibliographic Details
Published in:Journal of experimental & clinical cancer research 2021-01, Vol.40 (1), p.48-48, Article 48
Main Authors: Zhou, Mingyi, Yang, Zhuo, Wang, Danbo, Chen, Peng, Zhang, Yong
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Cell cycle
Cell cycle regulation
Cell growth
Cervical cancer
Chemotherapy
Circular RNAs
Development and progression
Gene expression
Mass spectrometry
MicroRNAs
Phosphorylation
Protein binding
Proteins
Radiation therapy
RNA
RNA binding protein
RNA Immunoprecipitation
Software
Transcription factors
Tumors
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As a novel type of non-coding RNA, circular RNAs (circRNAs) play a critical role in the initiation and development of various diseases, including cancer. However, the exact function of circRNAs in human cervical cancer remains largely unknown. We identified the circRNA signature of upregulated circRNAs between cervical cancer and paired adjacent normal tissues. Using two different cohorts and GEO database, a total of six upregulated circRNAs were identified with a fold change > 2, and P
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-021-01849-2