Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions

Pseudomonas aeruginosa , an antibiotic‐resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium...

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Bibliographic Details
Published in:Cellular microbiology 2024-01, Vol.2024 (1)
Main Authors: Patil, Sandip, Chen, Xiaowen, Wen, Feiqiu
Format: Article
Language:English
Subjects:
Antibiotics
Antibodies
Antigens
Antimicrobial agents
Biofilms
Combination therapy
Communication
CRISPR
Cystic fibrosis
Drug resistance
Gene expression
Gram-negative bacteria
Immune system
Immunotherapy
Investigations
Mortality
Nanoparticles
Nosocomial infections
Pathogenesis
Pathogens
Pseudomonas aeruginosa
Vaccines
Virulence
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Summary:Pseudomonas aeruginosa , an antibiotic‐resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small‐molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR‐Cas systems, and nanotechnology, show promise in preclinical studies. Despite advancements, challenges persist, prompting the need for a multifaceted approach targeting various aspects of P. aeruginosa pathogenesis for effective infection management. This review provides a comprehensive perspective on the status and future directions of innovative strategies against P. aeruginosa.
ISSN:1462-5814
1462-5822
DOI:10.1155/2024/7938723