Loading…

Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation

The clinical implementation of magnetic hyperthermia has experienced little progress since the first clinical trial was completed in 2005. Some of the hurdles to overcome are the reliable production of magnetic nanoparticles with controlled properties and the control of the temperature at the target...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-07, Vol.14 (8), p.1526
Main Authors: Luengo, Yurena, Díaz-Riascos, Zamira V, García-Soriano, David, Teran, Francisco J, Artés-Ibáñez, Emilio J, Ibarrola, Oihane, Somoza, Álvaro, Miranda, Rodolfo, Schwartz, Simó, Abasolo, Ibane, Salas, Gorka
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The clinical implementation of magnetic hyperthermia has experienced little progress since the first clinical trial was completed in 2005. Some of the hurdles to overcome are the reliable production of magnetic nanoparticles with controlled properties and the control of the temperature at the target tissue in vivo. Here, forty samples of iron oxide superparamagnetic nanoparticles were prepared by similar methods and thoroughly characterized in terms of size, aggregation degree, and heating response. Selected samples were intratumorally administered in animals with subcutaneous xenografts of human pancreatic cancer. In vivo experiments showed that it is possible to control the rise in temperature by modulating the field intensity during in vivo magnetic hyperthermia protocols. The procedure does not require sophisticated materials and it can be easily implemented by researchers or practitioners working in magnetic hyperthermia therapies.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14081526