Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis

Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT...

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Bibliographic Details
Published in:Multiple Sclerosis International 2014-01, Vol.2014 (2014), p.270-278
Main Authors: Fahrbach, K., Khankhel, Z., Wissinger, E., Huelin, R., Martin, A. L., Rao, S. M., Kim, E.
Format: Article
Language:English
Subjects:
Atrophy
Brain research
Cognitive ability
Diagnosis
Information processing
Magnetic resonance imaging
Meta-analysis
Multiple sclerosis
Patient outcomes
Processing speed
Review
Risk factors
Statistics
Studies
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Summary:Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atrophy were conducted. Results. The 39 studies identified frequently reported only significant correlations, suggesting reporting bias. Direct meta-analysis was only feasible for correlations between SDMT and T2LV ( r = - 0.45 , P < 0.001 ) and atrophy in patients with mixed-MS subtypes ( r = - 0.54 , P < 0.001 ). Familywise Holm-Bonferroni testing found that selective reporting was not the source of at least half of significant results reported. Binomial tests ( P = 0.006 ) favored SDMT over PASAT in strength of MRI correlations. Conclusions. A moderate-to-strong correlation exists between impaired IPS and MRI in mixed MS populations. Correlations with MRI were stronger for SDMT than for PASAT. Neither heterogeneity among populations nor reporting bias appeared to be responsible for these findings.
ISSN:2090-2654
2090-2662
DOI:10.1155/2014/975803