Dual midbrain and forebrain origins of thalamic inhibitory interneurons

The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus, where all thalamic interneurons can be traced b...

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Bibliographic Details
Published in:eLife 2021-02, Vol.10
Main Authors: Jager, Polona, Moore, Gerald, Calpin, Padraic, Durmishi, Xhuljana, Salgarella, Irene, Menage, Lucy, Kita, Yoshiaki, Wang, Yan, Kim, Dong Won, Blackshaw, Seth, Schultz, Simon R, Brickley, Stephen, Shimogori, Tomomi, Delogu, Alessio
Format: Article
Language:English
Subjects:
Animals
Automation
Brain
Callithrix
Cell Lineage
Cell Movement
Developmental Biology
Female
Forebrain
GABAergic lineages
GABAergic Neurons
Gene Expression Regulation, Developmental
In Situ Hybridization
inhibitory interneurons
Interneurons
Laboratories
Male
Marmoset
Mesencephalon
Mesencephalon - growth & development
Mice
Mice, Transgenic
Monkeys
Mouse
Neuroscience
Ontogeny
Prosencephalon - growth & development
Thalamus
Thalamus - cytology
Thalamus - growth & development
thalamus development
Tomography
two-photon tomography
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Summary:The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus, where all thalamic interneurons can be traced back to two developmental programmes: one specified in the midbrain and the other in the forebrain. Interneurons migrate to functionally distinct thalamocortical nuclei depending on their origin: the abundant, midbrain-derived class populates the first and higher order sensory thalamus while the rarer, forebrain-generated class is restricted to some higher order associative regions. We also observe that markers for the midbrain-born class are abundantly expressed throughout the thalamus of the New World monkey marmoset. These data therefore reveal that, despite the broad variability in interneuron density across mammalian species, the blueprint of the ontogenetic organisation of thalamic interneurons of larger-brained mammals exists and can be studied in mice.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.59272