Insular cortex Hounsfield units predict postoperative neurocardiogenic injury in patients with aneurysmal subarachnoid hemorrhage

• Published in: Annals of clinical and translational neurology 2023-12, Vol.10 (12), p.2373-2385
• Main Authors: Jia, Yitong, Lin, Fa, Li, Runting, Chen, Yu, Yang, Jun, Han, Heze, Wang, Ke, Yuan, Kexin, Zhao, Yang, Lu, Junlin, Li, Tu, Nie, Zhaobo, Zhou, Yunfan, Shi, Guangzhi, Li, Youxiang, Zhao, Yuanli, Chen, Xiaolin, Wang, Shuo
• Format: Article
• Language: English
• Subjects: Aneurysms; Brain research; Chi-square test; Hemorrhage; Hospitals; Humans; Insular Cortex; Kinases; Medical imaging; Software; Stroke; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - diagnostic imaging; Variables
• ISSN: 2328-9503; 2328-9503
• DOI: 10.1002/acn3.51926

Objective Our study aims to investigate the association between the Hounsfield unit (Hu) value of the insular cortex (IC) during emergency admission and the subsequent occurrence of post‐operative neurocardiogenic injury (NCI) among patients afflicted with aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients baseline characteristics were juxtaposed between those with and without NCI. The significant variables were incorporated into a multivariable stepwise logistic regression model. Receiver operating characteristic (ROC) curves were drafted for each significant variable, yielding cutoff values and the area under the curve (AUC). Subgroup and sensitivity analyses were performed to assess the predictive performance across various cohorts and ascertain result stability. Propensity score matching (PSM) was ultimately employed to redress any baseline characteristic disparities. Results Patients displaying a right IC Hu value surpassing 28.65 exhibited an escalated risk of postoperative NCI upon confounder adjustment (p