Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening...

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Bibliographic Details
Published in:Stem cell research 2022-04, Vol.60, p.102673-102673, Article 102673
Main Authors: Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J., Vadlamudi, Lata
Format: Article
Language:English
Subjects:
Cell Differentiation
Cellular Reprogramming
Drug Evaluation, Preclinical
Epilepsy
Humans
Induced Pluripotent Stem Cells - metabolism
Leukocytes, Mononuclear
Sendai virus
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Summary:In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2022.102673