Procoagulant Microvesicles in COVID-19 Patients: Possible Modulators of Inflammation and Prothrombotic Tendency

The hypercoagulability and thrombotic tendency in coronavirus disease 2019 (COVID-19) is multifactorial, driven mainly by inflammation, and endothelial dysfunction. Elevated levels of procoagulant microvesicles (MVs) and tissue factor-bearing microvesicles (TF-bearing MVs) have been observed in many...

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Published in:Infection and drug resistance 2022-01, Vol.15, p.2359-2368
Main Authors: Hamali, Hassan A, Saboor, Muhammad, Dobie, Gasim, Madkhali, Aymen M, Akhter, Mohammad S, Hakamy, Ali, Al-Mekhlafi, Hesham M, Jackson, Denise E, Matari, Yahya H, Mobarki, Abdullah A
Format: Article
Language:English
Subjects:
Coronaviruses
covid-19
d-dimer
Ethylenediaminetetraacetic acid
Inflammation
microvesicles
nlr
Original Research
plr
pnr
procoagulant
tissue factor
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Summary:The hypercoagulability and thrombotic tendency in coronavirus disease 2019 (COVID-19) is multifactorial, driven mainly by inflammation, and endothelial dysfunction. Elevated levels of procoagulant microvesicles (MVs) and tissue factor-bearing microvesicles (TF-bearing MVs) have been observed in many diseases with thrombotic tendency. The current study aimed to measure the levels of procoagulant MVs and TF-bearing MVs in patients with COVID-19 and healthy controls and to correlate their levels with platelet counts, D-Dimer levels, and other proposed calculated inflammatory markers. Forty ICU-admitted patients with COVID-19 and 37 healthy controls were recruited in the study. Levels of procoagulant MVs and TF-bearing MVs in the plasma of the study population were measured using enzyme linked immunosorbent assay. COVID-19 patients had significantly elevated levels of procoagulant MVs and TF-bearing MVs as compared with healthy controls (P
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S355395