Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as Prognostic Markers in Mammary Tumors

Inflammation results in the production of cytokines, such as interleukin- (IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-α with procarcinogenic activity. Furthermore, NF-κB is the major link between inflammation and tumorigenesis. This study verified the interaction between acti...

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Bibliographic Details
Published in:Mediators of inflammation 2016-01, Vol.2016 (2016), p.1-10
Main Authors: Maschio-Signorini, Larissa Bazela, Moschetta, Marina Gobbe, Gelaleti, Gabriela Bottaro, Martins, Gustavo Rodrigues, Zuccari, Debora Ap. Pires de Campos
Format: Article
Language:English
Subjects:
Animals
Cytokines - metabolism
Dogs
Female
Interleukin-10 - metabolism
Interleukin-4 - metabolism
Interleukin-6 - metabolism
NF-kappa B - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:Inflammation results in the production of cytokines, such as interleukin- (IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-α with procarcinogenic activity. Furthermore, NF-κB is the major link between inflammation and tumorigenesis. This study verified the interaction between active inflammatory cytokines in the tumor microenvironment and serum of female dogs with mammary tumors and their correlation with the clinicopathological characteristics and overall survival. Measurement of gene expression was performed by qPCR and protein levels by ELISA/Luminex. High gene and protein expression levels of NF-κB, IL-6, and TNF-α were found in association with characteristics that reflect worse prognosis and a negative correlation between TNF-α protein expression and survival time was observed (p
ISSN:0962-9351
1466-1861
DOI:10.1155/2016/9512743