The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses

IntroductionPrevious meta-analyses investigating the therapeutic effects of L-carnitine on lipid profiles have demonstrated inconsistent results. The present umbrella meta-analysis aimed to investigate the impact of efficacy of L-carnitine on lipid profiles in adults. MethodsDatabases including PubM...

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Published in:Frontiers in nutrition (Lausanne) 2023-09, Vol.10, p.1214734-1214734
Main Authors: Musazadeh, Vali, Alinejad, Hanie, Esfahani, Niloofar Kouhi, Kavyani, Zeynab, Keramati, Majid, Roshanravan, Neda, Mosharkesh, Erfan, Dehghan, Parvin
Format: Article
Language:English
Subjects:
dyslipidemia
L-Carnitine
lipid profile
Nutrition
systematic reviews
umbrella meta-analysis
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Summary:IntroductionPrevious meta-analyses investigating the therapeutic effects of L-carnitine on lipid profiles have demonstrated inconsistent results. The present umbrella meta-analysis aimed to investigate the impact of efficacy of L-carnitine on lipid profiles in adults. MethodsDatabases including PubMed, Scopus, and Embase, Web of Science, and Google Scholar were searched up to June 2023. Meta-analysis was performed using a random-effects model. ResultsOur results from thirteen meta-analyses indicated that L-carnitine supplementation significantly total cholesterol (TC) (ES = -1.05 mg/dL, 95% CI: -1.71, -0.39; p = 0.002), triglycerides (TG) (ES = -2.51 mg/dL; 95% CI: -3.62, -1.39, p 
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2023.1214734