Serum Organ-Specific Anti-Heart and Anti-Intercalated Disk Autoantibodies as New Autoimmune Markers of Cardiac Involvement in Systemic Sclerosis: Frequency, Clinical and Prognostic Correlates

• Published in: Diagnostics (Basel) 2021-11, Vol.11 (11), p.2165
• Main Authors: Caforio, Alida Linda Patrizia, De Luca, Giacomo, Baritussio, Anna, Seguso, Mara, Gallo, Nicoletta, Bison, Elisa, Cattini, Maria Grazia, Pontara, Elena, Gargani, Luna, Pepe, Alessia, Campochiaro, Corrado, Plebani, Mario, Iliceto, Sabino, Peretto, Giovanni, Esposito, Antonio, Tofani, Lorenzo, Moggi-Pignone, Alberto, Dagna, Lorenzo, Marcolongo, Renzo, Matucci-Cerinic, Marco, Bruni, Cosimo
• Format: Article
• Language: English
• Subjects: Antibodies; Asymptomatic; autoantibodies; autoimmunity; Cardiovascular disease; Coronary vessels; Data collection; Dyspnea; Ethics; Heart; Ischemia; Laboratories; Medical prognosis; Myocarditis; Normal distribution; Pain; Patients; prognosis; Rheumatology; RNA polymerase; Scleroderma; systemic sclerosis; Variables; Vein & artery diseases
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics11112165

Heart involvement (HInv) in systemic sclerosis (SSc) may relate to myocarditis and is associated with poor prognosis. Serum anti-heart (AHA) and anti-intercalated disk autoantibodies (AIDA) are organ and disease-specific markers of isolated autoimmune myocarditis. We assessed frequencies, clinical correlates, and prognostic impacts of AHA and AIDA in SSc. The study included consecutive SSc patients ( = 116, aged 53 ± 13 years, 83.6% females, median disease duration 7 years) with clinically suspected heart involvement (symptoms, abnormal ECG, abnormal troponin I or natriuretic peptides, and abnormal echocardiography). All SSc patients underwent CMR. Serum AHA and AIDA were measured by indirect immunofluorescence in SSc and in control groups of non-inflammatory cardiac disease (NICD) ( = 160), ischemic heart failure (IHF) ( = 141), and normal blood donors (NBD) ( = 270). AHA and AIDA status in SSc was correlated with baseline clinical, diagnostic features, and outcome. The frequency of AHA was higher in SSc (57/116, 49%, < 0.00001) than in NICD (2/160, 1%), IHF (2/141, 1%), or NBD (7/270, 2.5%). The frequency of AIDA was higher (65/116, 56%, < 0.00001) in SSc than in NICD (6/160, 3.75%), IHF (3/141, 2%), or NBD (1/270, 0.37%). AHAs were associated with interstitial lung disease ( = 0.04), history of chest pain ( = 0.026), abnormal troponin ( = 0.006), AIDA ( = 0.000), and current immunosuppression ( = 0.01). AHAs were associated with death ( = 0.02) and overall cardiac events during follow-up ( = 0.017). The high frequencies of AHA and AIDA suggest a high burden of underdiagnosed autoimmune HInv in SSc. In keeping with the negative prognostic impact of HInv in SSc, AHAs were associated with dismal prognosis.