Gellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral Candida albicans Infections

can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan...

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Published in:Pharmaceutics 2024-02, Vol.16 (3), p.298
Main Authors: Garcia, Maíra Terra, Carmo, Paulo Henrique Fonseca do, Figueiredo-Godoi, Lívia Mara Alves, Gonçalves, Natália Inês, Lima, Patrícia Michelle Nagai de, Ramos, Lucas de Paula, Oliveira, Luciane Dias de, Borges, Alexandre Luiz Souto, Shukla, Anita, Junqueira, Juliana Campos
Format: Article
Language:English
Subjects:
Acids
antifungal
Biofilms
Biomedical materials
caffeic acid phenethyl ester
Candida albicans
denture stomatitis
Drug delivery systems
gellan gum
Hydrogels
Infections
oral candidiasis
Spectrum analysis
Toxicity
Yeast
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Summary:can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively. First, we observed that different GG formulations (0.6 to 1.0% wt/vol) were able to incorporate and release CAPE, reaching a controlled and prolonged release over 180 min at 1.0% of GG. CAPE-GG formulations exhibited antifungal activity at CAPE concentrations ranging from 128 to >512 µg/mL. Furthermore, CAPE-GG formulations significantly decreased the fungal viability of biofilms at short times (12 h), mainly at 1.0% of GG ( < 0.001). protease activity was also reduced after 12 h of treatment with CAPE-GG formulations ( < 0.001). Importantly, CAPE was not cytotoxic to human keratinocytes, and CAPE-GG formulations at 1.0% decreased the fungal burden ( = 0.0087) and suppressed inflammation in a rat model of denture stomatitis. Altogether, these results indicate that GG is a promising delivery system for CAPE, showing effective activity against and potential to be used in the treatment of denture stomatitis.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16030298