Effectiveness of azithromycin mass drug administration on trachoma: a systematic review

Azithromycin mass drug administration (MDA) is a key part of the strategy for controlling trachoma. This systematic review aimed to comprehensively summarize the present studies of azithromycin MDA on trachoma; provide an overview of the impact of azithromycin MDA on trachoma in different districts;...

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Bibliographic Details
Published in:Chinese medical journal 2021-09, Vol.134 (24), p.2944-2953
Main Authors: Xiong, Tao, Yue, Yan, Li, Wen-Xing, Choonara, Imti, Qazi, Shamim, Chen, Hong-Ju, Tang, Jun, Shi, Jing, Wang, Hua, Zeng, Li-Nan, Xia, Bin, Qiao, Li-Na, Qu, Yi, Mu, De-Zhi
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotics
Azithromycin - therapeutic use
Bias
Children & youth
Drug dosages
Humans
Infant
Infections
Infectious diseases
Mass Drug Administration
Prevalence
Public health
Systematic Review
Trachoma - drug therapy
Trachoma - epidemiology
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Summary:Azithromycin mass drug administration (MDA) is a key part of the strategy for controlling trachoma. This systematic review aimed to comprehensively summarize the present studies of azithromycin MDA on trachoma; provide an overview of the impact of azithromycin MDA on trachoma in different districts; and explore the possible methods to enhance the effectiveness of azithromycin MDA in hyperendemic districts. PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials.gov were searched up to February 2021 with no language restriction. Studies reporting the effect of azithromycin MDA on trachoma were included. Mathematical modeling studies, animal studies, case reports, and reviews were excluded. The trachomatous inflammation-follicular (TF)
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000001717