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Surface-enhanced Raman spectroscopy reveals structure complexity difference in single extrapulmonary Mycobacterium tuberculosis bacteria with different drug resistance
In this work, we argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in hi...
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Published in: | Results in physics 2023-01, Vol.44, p.106106, Article 106106 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | In this work, we argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in high-wavenumber region. A discussion of drug resistance-related complexity of emerging specific vibrational bands for proteins and lipids forming a cell’s wall is provided.
•Surface enhanced Raman spectra of single mycobacteria are obtained.•Complexity of SERS spectra grows with drug resistance.•Drug resistance can be related to complexity of cell wall topology. |
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ISSN: | 2211-3797 2211-3797 |
DOI: | 10.1016/j.rinp.2022.106106 |