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Surface-enhanced Raman spectroscopy reveals structure complexity difference in single extrapulmonary Mycobacterium tuberculosis bacteria with different drug resistance

In this work, we argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in hi...

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Bibliographic Details
Published in:Results in physics 2023-01, Vol.44, p.106106, Article 106106
Main Authors: Lavrova, Anastasia I., Zyubin, Andrey, Dogonadze, Marine Z., Borisov, Evgenii V., Samusev, Ilya, Postnikov, Eugene B.
Format: Article
Language:English
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Summary:In this work, we argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in high-wavenumber region. A discussion of drug resistance-related complexity of emerging specific vibrational bands for proteins and lipids forming a cell’s wall is provided. •Surface enhanced Raman spectra of single mycobacteria are obtained.•Complexity of SERS spectra grows with drug resistance.•Drug resistance can be related to complexity of cell wall topology.
ISSN:2211-3797
2211-3797
DOI:10.1016/j.rinp.2022.106106