Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Hepatocellular carcinoma (HCC) is the second malignancy worldwide. POLA2 initiates DNA replication, regulates cell cycle and gene repair that promote tumorigenesis and disease progression. However, the prognostic and biological function roles of POLA2 in HCC had not been conclusively determined. The...

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Bibliographic Details
Published in:Cancer cell international 2023-07, Vol.23 (1), p.138-138, Article 138
Main Authors: Liu, Long, Wang, Qi, Wu, Linjun, Zhang, Lele, Huang, Yuxi, Yang, Haihua, Guo, Le, Fang, Zheping, Wang, Xuequan
Format: Article
Language:English
Subjects:
Cell cycle
Cell growth
Cell migration
Cell proliferation
Cell surface
Cell surface receptors
Cytotoxicity
DNA biosynthesis
DNA polymerase
DNA polymerase α
Genes
Genomes
Hepatocellular carcinoma
Immune checkpoint
Immune infiltration
Immune response
Infiltration
Liver cancer
Lymphocytes T
Malignancy
Medical prognosis
Medical research
Membrane proteins
Metastases
Metastasis
Microenvironments
mRNA
Mutation
POLA2
Prognosis
Prognostic
Proteins
Signal transduction
Software
Survival analysis
Therapeutic targets
Tumorigenesis
Tumors
Xenografts
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Summary:Hepatocellular carcinoma (HCC) is the second malignancy worldwide. POLA2 initiates DNA replication, regulates cell cycle and gene repair that promote tumorigenesis and disease progression. However, the prognostic and biological function roles of POLA2 in HCC had not been conclusively determined. The expression levels and prognosis role of POLA1 and POLA2 in HCC were analyzed based on TCGA-LIHC database and recruited 24 HCC patients. Gene mutations were analyzed using "maftools" package. POLA2 and immune cells correlations were analyzed by TIMER. POLA2 co-expressed genes functional enrichment were evaluated using Metascape. The mRNA and protein level of POLA2 was detected in HCC cells and tissues. Cell migration, invasion, proliferation, cell cycle and HCC cell lines derived xenograft model were performed to investigate POLA2 biological function. POLA2 was significantly high expressed in HCC than in normal liver tissue in both TCGA-LIHC and our collected HCC samples. In validation cohort, POLA2 significantly related to tumor differentiation, tumor size and Ki-67 (p 
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-023-02949-z