Comprehensive analysis of alternative polyadenylation regulators concerning CD276 and immune infiltration in bladder cancer

Alternative polyadenylation (APA) is emerging as a crucial regulatory mechanism in bladder cancer (BC), while it remains elusive whether APA influences the tumor immune microenvironment (TIME) in BC. We identified two distinct subtypes of BC by APA-related regulatory genes expression profiles. The t...

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Bibliographic Details
Published in:BMC cancer 2022-09, Vol.22 (1), p.1-1026, Article 1026
Main Authors: Xiong, Ming, Li, Wencheng, Wang, Longwang, Chen, Liang, Chen, Zhaohui, Wei, Chengcheng, Zhang, Futian, Chen, Jiawei, Kazobinka, Gallina, Zhao, Jun, Hou, Teng
Format: Article
Language:English
Subjects:
Alternative polyadenylation
Bladder cancer
CD276
Cluster analysis
Correlation analysis
CPSF3
Cytochrome
Disease
Gene expression
Genetic aspects
Health aspects
Immune infiltration
Immune response
Immunotherapy
Immunotherapy target
Infiltration
Medical prognosis
Metabolism
Metastases
Metastasis
Microenvironments
Polyadenylation
Prognosis
Risk factors
Roles
Survival analysis
Tumors
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Summary:Alternative polyadenylation (APA) is emerging as a crucial regulatory mechanism in bladder cancer (BC), while it remains elusive whether APA influences the tumor immune microenvironment (TIME) in BC. We identified two distinct subtypes of BC by APA-related regulatory genes expression profiles. The two subtypes have different pathological grades, prognostic outcomes, tumor immune infiltration characteristics, and pathway enrichment. Subsequently, CPSF3 was identified as a potential immune infiltration-related gene in BC. Highly expressed CPSF3 was positively correlated with unfavorable prognosis and high CD276 expression in BC. Moreover, we verified the expression of CPSF3 in BC tissues and cell lines by qRT-PCR. In conclusion, the study indicates that APA regulatory factors play an important role in immune infiltration of BC, and that CPSF3 was a potentially prognostic marker and immunotherapy target for BC.
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-022-10103-7