Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review

The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti- and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are af...

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Bibliographic Details
Published in:Current oncology (Toronto) 2022-07, Vol.29 (8), p.5247-5261
Main Authors: Li, Matu, Zheng, Ya, Zhao, Jinyu, Liu, Meimei, Shu, Xiaochuang, Li, Qiang, Wang, Yuping, Zhou, Yongning
Format: Article
Language:English
Subjects:
Biological Availability
Cancer
Care and treatment
Development and progression
gastric cancer
Gastrointestinal Microbiome
Humans
interaction
intestinal flora
mechanism
Microbiota (Symbiotic organisms)
Polyphenols
Polyphenols - pharmacology
Polyphenols - therapeutic use
Prevention
Review
Stomach cancer
Stomach Neoplasms - drug therapy
Tumor Microenvironment
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Summary:The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti- and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol29080417