Plant-based diet indices and their interaction with ambient air pollution on the ovarian cancer survival: A prospective cohort study

Ambient air pollution might serve as a prognostic factor for ovarian cancer (OC) survival, yet the relationships between plant-based diet indices (PDIs) and OC survival remain unclear. We aimed to investigate the associations of comprehensive air pollution and PDIs with OC survival and explored the...

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Published in:Ecotoxicology and environmental safety 2024-10, Vol.284, p.116894, Article 116894
Main Authors: Cao, Fan, Wang, Ran, Wang, Lan, Li, Yi-Zi, Wei, Yi-Fan, Zheng, Gang, Nan, Yu-Xin, Sun, Ming-Hui, Liu, Fang-Hua, Xu, He-Li, Zou, Bing-Jie, Li, Xiao-Ying, Qin, Xue, Huang, Dong-Hui, Chen, Ren-Jie, Gao, Song, Meng, Xia, Gong, Ting-Ting, Wu, Qi-Jun
Format: Article
Language:English
Subjects:
Adult
Aged
Air Pollutants - adverse effects
Air Pollutants - analysis
Air pollution
Air Pollution - adverse effects
Air Pollution - statistics & numerical data
Cohort Studies
Diet, Plant-Based
Diet, Vegetarian
Environmental Exposure - adverse effects
Environmental Exposure - statistics & numerical data
Female
Humans
Interaction
Middle Aged
Nitrogen Dioxide - analysis
Ovarian cancer
Ovarian Neoplasms - mortality
Ozone - analysis
Particulate Matter - analysis
Plant-based diet indices
Proportional Hazards Models
Prospective Studies
Survival
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Summary:Ambient air pollution might serve as a prognostic factor for ovarian cancer (OC) survival, yet the relationships between plant-based diet indices (PDIs) and OC survival remain unclear. We aimed to investigate the associations of comprehensive air pollution and PDIs with OC survival and explored the effects of air pollution-diet interactions. The present study encompassed 658 patients diagnosed with OC. The overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI) were evaluated by a self-reported validated food frequency questionnaire. In addition, an air pollution score (APS) was formulated by summing the concentrations of particulate matter with a diameter of 2.5 microns or less, ozone, and nitrogen dioxide. Cox proportional hazard models were applied to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs). The potential interactions of APS with PDIs in relation to overall survival (OS) were assessed on both multiplicative and additive scales. Throughout a median follow-up of 37.60 (interquartile: 24.77–50.70) months, 123 deaths were confirmed. Comparing to the lowest tertiles, highest uPDI was associated with lower OS of OC (HR = 2.06, 95 % CI = 1.30, 3.28; P-trend 
ISSN:0147-6513
1090-2414
1090-2414
DOI:10.1016/j.ecoenv.2024.116894