COMPARISON OF POLYURETHANE WITH CYANOACRYLATE IN HEMOSTASIS OF VASCULAR INJURY IN GUINEA PIGS

• Published in: Revista brasileira de cirurgia cardiovascular 2015-01, Vol.30 (1), p.119-126
• Main Authors: Kubrusly, Luiz Fernando, Formighieri, Marina Simões, Lago, José Vitor Martins, Graça, Yorgos Luiz Santos de Salles, Sobral, Ana Cristina Lira, Lago, Marianna Martins
• Format: Article
• Language: English
• Subjects: Biomedical materials; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiology; Cianoacrilatos; Cobaias; Comparative studies; Coronary vessels; Heart surgery; Hemostasia; Poliuretanos; Rodents; SURGERY; Óleo de Rícino
• ISSN: 0102-7638; 1678-9741; 1678-9741
• DOI: 10.5935/1678-9741.20140125

Objective: To evaluate the behavior of castor oil-derived polyurethane as a hemostatic agent and tissue response after abdominal aortic injury and to compare it with 2-octyl-cyanoacrylate. Methods: Twenty-four Guinea Pigs were randomly divided into three groups of eight animals (I, II, and III). The infrarenal abdominal aorta was dissected, clamped proximally and distally to the vascular puncture site. In group I (control), hemostasis was achieved with digital pressure; in group II (polyurethane) castor oil-derived polyurethane was applied, and in group III (cyanoacrylate), 2-octyl-cyanoacrylate was used. Group II was subdivided into IIA and IIB according to the time of preparation of the hemostatic agent. Results: Mean blood loss in groups IIA, IIB and III was 0.002 grams (g), 0.008 g, and 0.170 g, with standard deviation of 0.005 g, 0.005 g, and 0.424 g, respectively (P=0.069). The drying time for cyanoacrylate averaged 81.5 seconds (s) (standard deviation: 51.5 seconds) and 126.1 s (standard deviation: 23.0 s) for polyurethane B (P=0.046). However, there was a trend (P=0.069) for cyanoacrylate to dry more slowly than polyurethane A (mean: 40.5 s; SD: 8.6 s). Furthermore, polyurethane A had a shorter drying time than polyurethane B (P=0.003), mean IIA of 40.5 s (standard deviation: 8.6 s). In group III, 100% of the animals had mild/severe fibrosis, while in group II only 12.5% showed this degree of fibrosis (P=0.001). Conclusion: Polyurethane derived from castor oil showed similar hemostatic behavior to octyl-2-cyanoacrylate. There was less perivascular tissue response with polyurethane when compared with cyanoacrylate.