Pleuropulmonary blastoma: A report of three cases and review of literature

Pleuropulmonary blastoma is a rare and highly aggressive pulmonary malignancy in children. Clinically, the malignancy is often mistaken for symptoms of respiratory tract infection or pneumothorax. The neoplasm is histologically characterized by primitive blastema and a malignant mesenchymal stroma t...

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Bibliographic Details
Published in:Radiology case reports 2021-10, Vol.16 (10), p.2862-2868
Main Authors: Madaan, Prateek K., Sidhu, Harsumeet S., Girdhar, Smriti, Mann, Khushpreet K.
Format: Article
Language:English
Subjects:
Case Report
Contrast Enhanced Computed Tomography (CECT)
Pleuropulmonary Blastoma (PPB)
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Summary:Pleuropulmonary blastoma is a rare and highly aggressive pulmonary malignancy in children. Clinically, the malignancy is often mistaken for symptoms of respiratory tract infection or pneumothorax. The neoplasm is histologically characterized by primitive blastema and a malignant mesenchymal stroma that demonstrates multidirectional differentiation. The patients with PPB are managed by multimodal therapy. We present a report of 3 cases of histopathologically diagnosed pleuropulmonary blastoma. The patients presented with chief complaints of difficulty in breathing, cough, fever and chest pain. Radiographs of the patients showed partial to complete opacification of hemithorax. Contrast enhanced computed tomography scans revealed large well defined heterogenously enhancing solid mass lesions in the hemithorax. Knowledge of types, imaging findings, staging and association with other tumors is crucial for correct diagnosis of pleuropulmonary blastoma and subsequent adequate management.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2021.06.046