Inhibition of Biofilm Formation by Modified Oxylipins from the Shipworm Symbiont Teredinibacter turnerae

The bioactivity-guided purification of the culture broth of the shipworm endosymbiont strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid ( ), and two previously described oxylipins ( - ). Turneroic acid ( ) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compou...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2020-12, Vol.18 (12), p.656
Main Authors: Lacerna, 2nd, Noel M, Ramones, Cydee Marie V, Robes, Jose Miguel D, Picart, Myra Ruth D, Tun, Jortan O, Miller, Bailey W, Haygood, Margo G, Schmidt, Eric W, Salvador-Reyes, Lilibeth A, Concepcion, Gisela P
Format: Article
Language:English
Subjects:
Animals
anti-biofilm
Biofilms - drug effects
Biofilms - growth & development
Bivalvia
Gammaproteobacteria - chemistry
Lyrodus
Microbial Sensitivity Tests - methods
oxylipins
Oxylipins - isolation & purification
Oxylipins - pharmacology
shipworm
Staphylococcus epidermidis
Symbiosis - drug effects
Symbiosis - physiology
Teredinibacter turnerae
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The bioactivity-guided purification of the culture broth of the shipworm endosymbiont strain 991H.S.0a.06 yielded a new fatty acid, turneroic acid ( ), and two previously described oxylipins ( - ). Turneroic acid ( ) is an 18-carbon fatty acid decorated by a hydroxy group and an epoxide ring. Compounds - inhibited bacterial biofilm formation in , while only showed antimicrobial activity against planktonic . . Comparison of the bioactivity of - with structurally related compounds indicated the importance of the epoxide moiety for selective and potent biofilm inhibition.
ISSN:1660-3397
1660-3397
DOI:10.3390/md18120656