Detection of Human Bocavirus DNA by Multiplex PCR Analysis: Postmortem Case Report

Human bocavirus (HBoV) is a virus belonging to the Parvoviridae family, which has been newly discovered to be associated with respiratory tract infections in children. There are many reports worldwide on the endemicity of this virus. Since it is relatively new, it is not routinely detected in clinic...

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Bibliographic Details
Published in:Balkan medical journal 2015-04, Vol.32 (2), p.226-229
Main Authors: Ziyade, Nihan, Şirin, Gözde, Elgörmüş, Neval, Daş, Taner
Format: Article
Language:English
Subjects:
Autopsy
Case Report
forensic science
human bocavirus
multiplex PCR
postmortem microbiology
respiratory tract infection
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Summary:Human bocavirus (HBoV) is a virus belonging to the Parvoviridae family, which has been newly discovered to be associated with respiratory tract infections in children. There are many reports worldwide on the endemicity of this virus. Since it is relatively new, it is not routinely detected in clinical laboratory investigations. We demonstrated that HBoV infection caused the death of a 5-month-old girl with a history of high fever and wheezing. Human bocavirus (HBoV 1/2/3/4) was found in a nasopharyngeal swab, paraffin-embedded lung tissue and stool samples by multiplex PCR methods using postmortem microbiological analysis. This case suggests that lower respiratory tract infections due to HBoV may cause severe and life-threatening diseases. Postmortem microbiology is useful in both clinical and forensic autopsies, and allows a suspected infection to be confirmed. To our knowledge, this report is the first document of a HBoV postmortem case in Turkey.
ISSN:2146-3123
2146-3131
DOI:10.5152/balkanmedj.2015.15254