Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy

Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests that Tregs may be eliminated or functionally inhibited to stimulate antitumor immunity. Howev...

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Bibliographic Details
Published in:Biomarker research 2024-04, Vol.12 (1), p.41-41, Article 41
Main Authors: Shan, Yukai, Xie, Tianao, Sun, Yuchao, Lu, Ziyi, Topatana, Win, Juengpanich, Sarun, Chen, Tianen, Han, Yina, Cao, Jiasheng, Hu, Jiahao, Li, Shijie, Cai, Xiujun, Chen, Mingyu
Format: Article
Language:English
Subjects:
Antigens
Autoimmune diseases
Body fat
Cancer
Chemokines
Cholesterol
Cytokines
Development and progression
Effector cells
Energy
Fatty acids
Genotype & phenotype
Glucose
Immune checkpoint
Immune system
Immunomodulation
Immunoregulation
Immunosuppression
Immunotherapy
Inflammation
Kinases
Lipid metabolism
Lipids
Lymphocytes
Lymphocytes T
Medical prognosis
Metabolic competition
Metabolic regulatory switches
Metabolism
Oxidation
Phosphorylation
Physiological aspects
Proteins
Review
T cells
Transcription factors
Tregs
Tumor therapies
Tumor-infiltrating lymphocytes
Tumors
Type 2 diabetes
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Summary:Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor development. The abundance of Tregs in tumor tissues suggests that Tregs may be eliminated or functionally inhibited to stimulate antitumor immunity. However, immunotherapy targeting Tregs has been severely hampered by autoimmune diseases due to the systemic elimination of Tregs. Recently, emerging studies have shown that metabolic regulation can specifically target tumor-infiltrating immune cells, and lipid accumulation in TME is associated with immunosuppression. Nevertheless, how Tregs actively regulate metabolic reprogramming to outcompete effector T cells (Teffs), and how lipid metabolic reprogramming contributes to the immunomodulatory capacity of Tregs have not been fully discussed. This review will discuss the physiological processes by which lipid accumulation confers a metabolic advantage to tumor-infiltrating Tregs (TI-Tregs) and amplifies their immunosuppressive functions. Furthermore, we will provide a summary of the driving effects of various metabolic regulators on the metabolic reprogramming of Tregs. Finally, we propose that targeting the lipid metabolism of TI-Tregs could be efficacious either alone or in conjunction with immune checkpoint therapy.
ISSN:2050-7771
2050-7771
DOI:10.1186/s40364-024-00588-8