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Practice guidelines for the management of extranodal non-Hodgkin's lymphomas of adult non-immunodeficient patients. Part I: primary lung and mediastinal lymphomas. A project of the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation
1 Istituto di Ematologia ed Oncologia Medica "Seragnoli", Università di Bologna, Bologna 2 Cattedra di Ematologia, Università La Sapienza, Roma 3 Interventional Pneumology Unit, Morgagni Hospital, Forlì 4 Cattedra di Ematologia 2, Azienda Ospedaliera San Giovanni Battista, Torino 5 Departm...
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Published in: | Haematologica (Roma) 2008-09, Vol.93 (9), p.1364-1371 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | 1 Istituto di Ematologia ed Oncologia Medica "Seragnoli", Università di Bologna, Bologna
2 Cattedra di Ematologia, Università La Sapienza, Roma
3 Interventional Pneumology Unit, Morgagni Hospital, Forlì
4 Cattedra di Ematologia 2, Azienda Ospedaliera San Giovanni Battista, Torino
5 Department of Internal Medicine and Oncology, IRCCS Policlinico S.Matteo Foundation, Pavia
6 Hematology Division, Civil Hospital, University of Venice, Mestre
7 Laboratory of Clinical Epidemiology, IRCCS Policlinico S.Matteo Foundation, Pavia
8 Department of Radiochemotherapy, San Raffaele Hospital, Milan
9 Dermatology Unit II, Department of Dermatological Sciences, University of Florence, Florence, Italy
Correspondence: Giovanni Barosi, MD, Laboratory of Clinical Epidemiology, IRCCS Policlinico S. Matteo Foundation, viale Golgi 19, 27100, Pavia, Italy. E-mail: barosig{at}smatteo.pv.it
ABSTRACT
Extranodal non-Hodgkins lymphomas constitute 20–25% of overall non-Hodgkins lymphomas cases and can be managed with very different therapeutic strategies. Therefore, the Italian Society of Hematology and the two affiliate societies (the Italian Society of Experimental Hematology and the Italian Group of Bone Marrow Transplantation) appointed a panel of experts to produce clinical practice-guidelines for the management of these conditions. Primary lung and mediastinal lymphomas were the objective of this part of the project. The panel of experts produced the following key recommendations that were graded according to the strength of evidence and clinical judgement. The first-line therapy for non-MALT primary lung non-Hodgkins lymphomas should include anthracycline-based chemotherapy with CHOP or CHOP-like, MACOP-B or MACOP-B-like regimens (grade D). Rituximab association with chemotherapy needs to be evaluated within approved clinical trials. Second-line therapy with high-dose chemotherapy and autologous stem cell transplantation is recommended (grade B). In patients with MALT primary lung non-Hodgkins lymphomas, the recommended first-line therapy should include chlorambucil, CHOP, CHOP-like or fludarabine-containing regimens (grade B). Radiotherapy is to be reserved for patients with a unique, small lesion in a poorly mobile site and with contraindication to surgery (grade D). Rituximab should be administered only within approved clinical trials. For treatment of primary mediastinal large B-cell lymphomas, the recommended first-line therapy is a chemotherapy and radiotherapy associati |
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ISSN: | 0390-6078 1592-8721 |
DOI: | 10.3324/haematol.12742 |