t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc)...

Full description

Saved in:
Bibliographic Details
Published in:Molecular cancer 2007-06, Vol.6 (1), p.35-35
Main Authors: Liu, Delong, Shimonov, Josif, Primanneni, Suneeta, Lai, Yongrong, Ahmed, Tauseef, Seiter, Karen
Format: Article
Language:English
Subjects:
Burkitt Lymphoma - drug therapy
Burkitt Lymphoma - genetics
Burkitt Lymphoma - radiotherapy
Burkitt's lymphoma
Case studies
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 14 - ultrastructure
Chromosomes, Human, Pair 18 - genetics
Chromosomes, Human, Pair 18 - ultrastructure
Chromosomes, Human, Pair 8 - genetics
Chromosomes, Human, Pair 8 - ultrastructure
Combined Modality Therapy
Female
Genes, bcl-2
Genes, Immunoglobulin
Genes, myc
Genetic aspects
Humans
Immunoglobulin Heavy Chains - genetics
Karyotyping
Male
Middle Aged
Physiological aspects
Remission Induction
Short Communication
Translocation (Genetics)
Translocation, Genetic
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.
ISSN:1476-4598
1476-4598
DOI:10.1186/1476-4598-6-35