Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activi...

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Bibliographic Details
Published in:Scientific reports 2021-02, Vol.11 (1), p.3769-3769, Article 3769
Main Authors: Hachiya, Tsuyoshi, Kobayashi, Takuro, Tsutae, Wataru, Gan, Pamela Hui Peng, Baran, Iri Sato, Horie, Shigeo
Format: Article
Language:English
Subjects:
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Adult
Aged
Aged, 80 and over
Aging
Aging - genetics
Blood
Chromosome Deletion
Chromosomes, Human, Y - genetics
Cigarette Smoking - genetics
Exercise - genetics
Humanities and Social Sciences
Humans
Japan
Leukocytes
Leukocytes - metabolism
Male
Middle Aged
Mosaicism
multidisciplinary
Physical activity
Saliva
Saliva - chemistry
Saliva - cytology
Science
Science (multidisciplinary)
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Summary:Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-83308-8